Randomized trial of sertraline, prolonged exposure and their combination for PTSD and OEF/OIF (2010-2016)

You are here

Funded by Veterans Education Research Association of Michigan

Funding Years: 2010-2016

This research study aims to compare the effectiveness of two proven treatments for posttraumatic stress disorder (PTSD): Prolonged Exposure (PE), sertraline, and their combination. In addition, the investigators are examining predictors of response to these two treatments and how PTSD symptoms, thoughts, and biological factors may be changed by such treatments. Biological mechanisms of change are also examined including emotion processing and regulation in fMRI, HPA axis function, and genetics and genomics. The investigators are also examining acceptability of each treatment and reasons for ending treatment.

PI(s): Sheila Rauch

Co-I(s): H. Myra Kim